ACEIP-DB is an open-access, manually curated database dedicated to angiotensin-converting enzyme (ACE, EC 3.4.15.1) inhibitory peptides. It provides comprehensive annotations including sequences, physicochemical properties, IC₅₀ values, biological sources, and literature references for antihypertensive peptide research.
ACEIP-DB (ACE Inhibitory Peptide Database) is a comprehensive, manually curated resource for angiotensin-converting enzyme inhibitory peptides. The database currently contains 1,193 validated entries covering peptide sequences ranging from 2 to 50 amino acids, sourced from diverse biological origins including milk, fish, cereals, plants, and synthetic constructs.
Each entry is annotated with sequence information, IC₅₀ values (when available), physicochemical properties (molecular weight, isoelectric point, net charge, GRAVY index, instability index, hydrophobicity, Boman index), secondary structure composition, detailed source information, and literature references with DOI and PubMed links.
The database aims to facilitate research in antihypertensive peptide discovery, QSAR modeling, and computational peptide design.
If you use ACEIP-DB in your research, please cite:
School of Life Science and Technology, China Pharmaceutical University, Nanjing, China
This database is sponsored by Zheng's Lab.
Tip: Search by ACEIP ID (e.g., aceip0001), peptide sequence (e.g., VVYPW), or biological source (e.g., Milk, Fish).
Set your filter criteria and click "Search" to find peptides.
| Dataset | Format | Description | Action |
|---|---|---|---|
| Full Database | CSV | All entries with complete annotations | ⬇ Download |
| Sequences Only | FASTA | Peptide sequences in FASTA format | ⬇ Download |
| Full Database | JSON | All entries in JSON format (for developers) | ⬇ Download |
ACEIP-DB is freely available for academic and non-commercial research. If you use data from ACEIP-DB, please cite the original database publication and the relevant literature for individual entries. Redistribution of the complete dataset requires prior written permission.
Simple Search: Use the search bar to find entries by ACEIP ID, peptide sequence, or biological source.
Advanced Search: Combine multiple filters — ID, sequence, length, source, molecular weight, pI, charge, GRAVY, instability, Boman index, DOI, and PubMed ID.
Browse: View all entries in a sortable, paginated table. Click any entry to see full details.
Downloads: Export the complete dataset in CSV, FASTA, or JSON format.
ACEIP ID: Unique identifier (aceip0001–aceip1193)
Sequence: Amino acid sequence in one-letter code
IC₅₀: Half-maximal inhibitory concentration for ACE
MW: Molecular weight in Daltons
pI: Isoelectric point
GRAVY: Grand average of hydropathicity
Boman Index: Protein-binding potential
Instability: In-vivo instability prediction
How is IC₅₀ data collected?
IC₅₀ values are manually curated from peer-reviewed literature. Values are reported as published, with original units preserved (μM, mM, mg/ml, etc.).
What physicochemical tools were used?
Properties were calculated using established peptide analysis algorithms for MW, pI, GRAVY, instability index, and secondary structure prediction.
Can I submit new peptide data?
Yes! Use the Submit page or email your data directly. We accept new ACE inhibitory peptide data with supporting literature references.
We welcome contributions of new ACE inhibitory peptide data. To submit entries, please provide at minimum the peptide sequence, IC₅₀ value, source, and a supporting reference.
Please send your data via email to: qianzh@stu.cpu.edu.cn
Required information per entry: Peptide Sequence, IC₅₀ Value (if available), Biological Source, Reference Title, DOI or PubMed ID.